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ea0041ep954 | Steroid metabolism + action | ECE2016

First generation testosterone assays are influenced by sex hormone binding globulin concentrations as evidenced during oral contraceptive use and pregnancy

Heijboer Annemieke , Savelkoul Edo , Kruit Adrian , Endert Erik , Blankenstein Marinus

Introduction: The quality of testosterone assays has been a matter of debate for several years. Known limitations of testosterone immunoassays are the cross-reactivity with other steroids and a high variation in the low concentration range. We hypothesized that one of the additional limitations of testosterone immunoassays is an ineffective displacement of testosterone from its binding protein.Methods: Thirty samples from women not using oral contracepti...

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ea0099rc6.1 | Rapid Communications 6: Thyroid | Part I | ECE2024

Age-specific reference intervals for TSH and FT4 to optimize diagnosis of thyroid disease

Jansen Heleen , Dirks Niek , Hillebrand Jacquelien , Ten Boekel Edwin , Brinkman Jacoline , Buijs Madelon , Demir Ayse , Dijkstra Ineke , Endenburg Silvia , Engbers Paula , Gootjes Jeannette , Janssen Marcel , Kamphuis Stephan , Kniest-de Jong Wilhelmina , Kruit Adrian , Michielsen Etienne , Wolthuis Albert , van Trotsenburg A.S. Paul , den Heijer Martin , Bruinstroop Eveline , Boelen Anita , Heijboer Annemieke C , den Elzen Wendy

Introduction: Thyroid disorders are generally diagnosed based on thyroid stimulating hormone (TSH) outside the reference interval (RI), and subsequent free thyroxine (FT4) concentrations. Most laboratories do not provide age-specific RIs for TSH and FT4 beyond childhood, although it is known that TSH concentrations vary with age which may be important to take into account. Therefore, we aimed to establish age-specific RIs for TSH and FT4 throughout life using an indirect metho...

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Endocrine Abstracts

First generation testosterone assays are influenced by sex hormone binding globulin concentrations as evidenced during oral contraceptive use and pregnancy

Age-specific reference intervals for TSH and FT4 to optimize diagnosis of thyroid disease

BiosciAbstracts